THE ROLE OF EFFECTIVE COMMUNICATION IN THE MANAGEMENT AND RESOLUTION OF INDUSTRIAL CRISES
THE EFFECT OF ETHANOL EXTRACT OF DESMODIUM VELUTINUM STEM ON SOME MARKER EMZYME IN LIVER OF ALBINO WISTAR RATS
December 4, 2017
THE ROLE OF EFFECTIVE COMMUNICATION IN THE MANAGEMENT AND RESOLUTION OF INDUSTRIAL CRISES
THE EFFECT OF PTEROCARPUS MILDBREADII SEED ON PLASMA HDL CHOLESTEROL OF ALBINO RAT
December 4, 2017
Show all

THE EFFECT OF N-HEXANE EXTRACT OF KOLA NITIDA BARK ON LIVER FUNCTION TEST OF ALBINO WISTAR RATS FED WITH HIGH FAT FROM COW‘S BRAIN

 3,000

Category:

Contact Us

    08165312322, 08119982823
    08165312322

RESEARCH INFORMATION

: THE EFFECT OF N-HEXANE EXTRACT OF KOLA NITIDA BARK ON LIVER FUNCTION TEST OF ALBINO WISTAR RATS FED WITH HIGH FAT FROM COW‘S BRAIN
: Chapter 1 – 5
: 47 Pages
: #3, 000
: Ms Word format

This study,THE EFFECT OF N-HEXANE EXTRACT OF KOLA NITIDA BARK ON LIVER FUNCTION TEST OF ALBINO WISTAR RATS FED WITH HIGH FAT FROM COW‘S BRAIN contains concise information that will serve as a framework or guide for your project work. The project study is well-researched for academic purposes and are usually provided in complete chapters with adequate References.

Keywords:THE EFFECT OF N-HEXANE EXTRACT OF KOLA NITIDA BARK ON LIVER FUNCTION TEST OF ALBINO WISTAR RATS FED WITH HIGH FAT FROM COW‘S BRAIN


ju

RESEARCH BODY

ABSTRACT

Kola bark extract have been widely used in tradition medicine for thousand of year, it improves liver functions and provides protection against high fat fed metabolic rats. Present investigations were carried out on the hepatoprotective role of Kola bark extract meal treatment to high fat fed wistar rat. Healthy adult male wistar rats were divided into four groups Group I: rats were fed a standard Laboratory diet (groups match) (20g/rat/day), Group II: rats were fed a high-fat diet alone (3.6g/rat/day), Group III: rats were fed with combined mixture of 70% of high-fat diet with 30% Kola bark meal (9.8g/rat /day), Group/ V: rats were fed with high fat diet and was administered with Lipitor (Atovastatin) (10mg/rat/day) . The rats were sacrificed at the end of the experiment (two weeks) period. The high fat fed rat substantially elevated its serum and liver tissue AST, ALT, ALP, bilirubin with decreased in total protein levels. Where as the levels of all parameters significantly restored towards normalization by the kola bark husk meal treatment. The results obtained suggest that the Kola bark meal have potent hepatoprotective action on high fat fed rats. A companion of the performance in both Kola bark meal and Lipitor treatment on high fat fed rat in respect of hepatoprotective role is clearly indicator that the Kola bark meal treatment was more and related to the result of Lipitor as well as to the normal level.

CHAPTER ONE

1.0    INTRODUCTION

BACKGROUND OF THE STUDY

Liver is the largest and most complex internal organ in the body. It plays an important role in the maintenance of internal environment through its multiple and diverse functions. Liver is involved in several vital functions such as metabolism, secretion and storage. Hepatitis or inflammatory disorder involves inflammation and damage to the hepatocytes. Hepatitis is one of the most prevalent diseases in the world. Every year 18,000 people had been reported to die due to liver cirrhosis caused by viral hepatitis [L] Ectopic fat storage occurs in obesity particularly in the liver leading to a condition termed nonalcoholic fatty liver disease [NAFLD] characterized by varying degree of liver injury that progresses from steatosis to tratohepatitis, fibrosis and necrosis Due to its prominent association with IR (insulin resistance). Obesity, NAFLD is regarded as the hepatic manifestation of metabolite [3] syndrome. Liver has great capacity to detoxicate toxic substances.

Kola pod is the traditional health food around the world. Kola pod Husk meal is the residue after grinding the pod of kola and filtration, and it is an excellent source in slightly high in fiber (16.74%), low in crude protein (9.98%), moderate NFE (42.391) and metabolizable energy 2497 kcal/kg, and

ash content is relatively high. (13.26%). when companied with the values reported by (Oluokun, 1999) ;(Hamzat and Babatunde, 2001). These differences might be due to varietals differenced and shelf life of the test ingredient before analysis. However, the crude protein content fairly put kola pod husk meal (KPHM) with feed ingredients like Sorghum while the fibre content put it in same proximate composition with Bremer‘s grains. Kola pod being one of the important pods for medical treatment in the world. The kola pod husk provides some essential materials for doth drying. The pod bark, when mixed with some ingredients is used in traditional medicine to reduce Labour pains. The bark is used in treating swellings and fresh wounds. The roots provide excellent chewing sticks for cleaning the teeth and the wood is used in local carvings coachwork and boatbuilding. Lipid refers to the different kind of fats present in the bodies of human plasma include triglyceride (TG), phospholipids (PL), cholesterol esters (CE), and free cholesterol (FC) and non-esterified fatty acid (NEFA. Each lipid plays a different role in our bodies yet all of them except free cholesterol (FC) contain esters of long chain fatty acid in their structures. Lipids are insoluble in plasma due to their non- polar structures thus; they need some carriers that are soluble in polar and non- polar environment. Lipids are packaged and carried

in the form of lipoprotein, which is a molecule that contains both protein (i.e. apolipoprotein) and lipids.

Statins (lipitor) are group of drugs approved for their Cholesterol reduction properties and are commonly used to treat atherosclerosis and coronary artery disease. These drugs inhibit 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-COA) reductase. The rate limiting enzyme in cholesterol biosynthesis; which converts HMG.CoA to mevalonate. Apart from cholesterol, mevalonate is also the substrate for the synthesis of nonsteroid, isoprenoids such as coenzyme Q. Depletion of these isoprenoids results in the so called plelotropic effects of statins which are independent of cholesterol.

Lowering effect.These plelotropic effects of anti-inflammatory, anti-apoptotic and ant-proliferative effect. In addition, data from experimental and observational studies indicated that statins have neuroprotective effects and be a treatment option for neurodegenerative diseases of the central nervous system and the ocular structures particularly the retina (schemer, 2007). Statins (Atorvastatin) is widely used in the treatment of hepatic diseases. They have been widely used in chinning proactive as cholesterol lowering agents to reduce mobility and mortality from coronary artery diseases. It also has an effect in inflammatory diseases such as rheumatoid arthritis, and multiple sclerosis.

However, limited studies are available on the effect of kola pod husk meal treatment on hepatoprotective effect in high fat diet fed animal in this regard, the present study was aimed to investigate the effect of kola pod meal on high-fat fed rats related to different hepatoprotective effect by comparing Lipitor Treatment.

Keywords: THE EFFECT OF N-HEXANE EXTRACT OF KOLA NITIDA BARK ON LIVER FUNCTION TEST OF ALBINO WISTAR RATS FED WITH HIGH FAT FROM COW‘S BRAIN


ju


NOTE: INSTANT DOWNLOAD SERVICE

Have you made payment for this project? If YES, Get a Download Code by contacting our Customer Care.

For further enquiries, call our Hotlines: (+234) 0816-531-2322, 0811-998-2823


PROJECT TOPICS AND MATERIALS | HIRE A WRITER | HOW TO PAY FOR PROJECT

Keywords: THE EFFECT OF N-HEXANE EXTRACT OF KOLA NITIDA BARK ON LIVER FUNCTION TEST OF ALBINO WISTAR RATS FED WITH HIGH FAT FROM COW‘S BRAIN

Got something to discuss?


 

HOW DO I MAKE PAYMENT FOR THIS PROJECT





Not the topic you are looking for ? Search here


DISCLAIMER: myproject.com.ng focus on attracting students and researchers to materials that can be used as guide, framework, and reference for their project work. All contents/materials on this website are for research purposes only and for no reason should you copy verbatim. This platform is not encouraging any form of plagiarism, neither are we advocating the use of the project materials for cheating. We strictly recommend that research project topics and materials ordered for should serve as a guide or framework only. The contents therein should be used to generate fresh ideas for your own research. Finally, myproject.com.ng will not be liable for any material used inappropriately.