STUDY ON THE EFFECT OF ALLIUM ASCALONICUM ETHANOLIC EXTRACT ON LIVER FUNCTIONS: ASP, ALT, AST, DIRECT AND TOTAL BILIRUBIN IN ADULT WISTAR RATS

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RESEARCH INFORMATION

[icon type=”icon-pencil”]: STUDY ON THE EFFECT OF ALLIUM ASCALONICUM ETHANOLIC EXTRACT ON LIVER FUNCTIONS: ASP, ALT, AST, DIRECT AND TOTAL BILIRUBIN IN ADULT WISTAR RATS
[icon type=”icon-book”]: Chapter 1 – 5
[icon type=”icon-book-open”]: 69 Pages
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[icon type=”icon-doc-line”]: Ms Word format

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Keywords: STUDY ON THE EFFECT OF ALLIUM ASCALONICUM ETHANOLIC EXTRACT ON LIVER FUNCTIONS: ASP, ALT, AST, DIRECT AND TOTAL BILIRUBIN IN ADULT WISTAR RATS


RESEARCH BODY

 ABSTRACT

The effect of ethanolic extract of Allium Ascallonicum was evaluated in male and female wistar rat during 14 days after the doses of (300, 500, 700)mg/kg body weight orally. Parameter evaluated include serum ASP, AST, ALT, direct bilirubin and Total bilirubin.20 wistar rats were divided into four groups with weight range of (150±20)g the group 1 is the control group ,group(ii,iii,iv) are treated with the extract in varying concentration of (300,500,700)mg/kg body weight respectively. The result showed that the groups treated with A. ascalonicum insignificantly increased in AST, ALT and ALP parameter by (p>0.05) and insignificant decreased in direct and total bilirubin parameter by (p>0.05).

TABLE OF CONTENTS

 CHAPTER ONE

1.0     Introduction

1.1     Aim of Study

CHAPTER TWO

2.0     Literature review

2.1     Allium ascalonicum, its uses and phytochemicals

2.1.1  Liver protective effect of hydroalcoholic extract of Allium Ascalonicum in rats with alloxan-induced diabetes mellitus

2.1.2  An invivo toxicological study upon shallomin, the active

Antimicrobial constitute of shallot extract

2.1.3  Anticancer and Anti-inflammatory activities of shallot

2.2     Liver

2.2.1  Liver diseases

2.2.2  Liver enzymes

2.2.3  Alkaline phosphatase

2.2.5  Aspartate transaminase

2.2.6  Transaminitis

2.2.7  Total bilirubin

2.2.8  Direct bilirubin

2.2.9  Congenital bilirubin disorders

2.3     High bilirubin in neonates

CHAPTER THREE

3.1     Materials and Methods

3.2     Apparatus and Equipments

3.3     Reagents

3.4     Ethanol extract preparation

3.5     Experimental animals

3.6     Plant extract administration

3.7     Categorization

3.8     Blood sampling and biochemical methods

3.9     Statistical analysis of data

CHAPTER FOUR

4.1     Results

CHAPTER FIVE

5.0     Discussion , Conclusion and Recommendation

5.1     Discussion

5.2     Conclusion

5.3     Recommendation

References

Appendix

LIST OF TABLE

Table 1 – Showing the mean plasma level of ALP, ALT, AST, direct bilirubin and total bilirubin

LIST OF FIGURES

Figure 1- Diagram of Allium ascalonicum

Figure 2 – Diagram of the liver

Figure 3 – Barchat showing the level of Alkaline phosphatase in blood plasma of control and experimental groups

Figure 4 – Barchat showing the level of Alanine aminotransferase in  blood plasma of control and experimental groups

Figure 5 – Barchat showing the level of Aspartate aminotransferase in  blood plasma of control and experimental groups

Figure 6 – Barchat showing the level of direct bilirubin in blood plasma of control and experimental groups

Figure 7 – Barchat showing the level of Total bilirubin in blood plasma of control and experimental groups

 

Keywords: STUDY ON THE EFFECT OF ALLIUM ASCALONICUM ETHANOLIC EXTRACT ON LIVER FUNCTIONS: ASP, ALT, AST, DIRECT AND TOTAL BILIRUBIN IN ADULT WISTAR RATS



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Keywords: STUDY ON THE EFFECT OF ALLIUM ASCALONICUM ETHANOLIC EXTRACT ON LIVER FUNCTIONS: ASP, ALT, AST, DIRECT AND TOTAL BILIRUBIN IN ADULT WISTAR RATS

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